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However, folate deficiency, either associated or not associated with the thermolabile mutation of the N 5,10 -methylenetetrahydrofolate reductase, and vitamin B 6 deficiency, perhaps associated with cystathionine β-synthase defects or with methionine excess, are believed to be major determinants of the increased risk of cardiovascular disease related to hyperhomocysteinemia
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Additionally, it has been suggested that SSD reduces renal inflammation and apoptosis in a sepsis mouse model by inhibiting the transcription factor-7 (TCF7)/Fos-like antigen 1/matrix metalloproteinase (MMP)-9 axis (24), supporting its protective role in renal inflammation